The ERA test is one of the methods that significantly increases the chances of pregnancy. Most of the negative results of IVF treatment are due to the egg, sperm and embryo. Womb tissue and the condition of the womb onto which the embryo must attach are as important as the embryo itself. The ERA test plays a role in preparing the appropriate conditions for the embryo.
Generally, an ultrasonography or a hysteroscopy are used in the routine examinations conducted during treatment in the clinics. During these examinations, certain pathologies (myoma, polyp, curtain, indentation in the upper womb wall etc.) that prevent pregnancy can be found and these pathologies can generally be solved through surgery. On the other hand, other than these pathologies, it is not possible to determine with these methods how healthy the cell level micro-surroundings for the embryo to attach onto are, and whether or not these surroundings are suitable for the embryo.
Research conducted in recent years, especially on couples who have had two or more high quality embryo transfers but have not yet obtained pregnancy, has resulted in the following conclusions:
- The womb tissue does not show synchronised development with the embryo
- The womb tissue does not reach a sufficient level maturity for the embryo to attach onto when the embryo is ready for pregnancy.
The ERA test is useful in such cases. The ERA test helps determine when the womb tissue is at the optimal stage for the embryo. Therefore, it is now possible to foresee when the embryo transfer should be conducted for the pregnancy success rate to be high.
The use of ERA Test in Donation Treatments
Due to the eggs and sperms being used in donation treatments having a high potential to impregnate, most of the treatment focuses on ensuring that the womb tissue accepts the embryo. The results obtained from the ERA test help increase the chances of pregnancy by helping determine the treatment program and embryo transfer day of some patients. According to the results obtained with the ERA test, it is often possible to determine the reasons for negative results in previous attempts.
How is the ERA Test Applied?
The patient’s internal womb wall is monitored with a program when their menstruation begins. Then, on a day planned by the doctor, a small sample of endometrial is taken with a biopsy. The removal of the tissue sample is a very simple procedure and is conducted in an operating theatre where the patient is generally given some sedatives to ensure their comfort. The tissue sample is subjected to detailed analysis with further genetic diagnosis methods that search over 230 gene regions and gene substances. The results are evaluated in approximately 4 weeks and the womb’s potential to accept the embryo is determined. Ultimately, it is determined whether or not the embryo can attach onto the tissue. The embryo transfer day is determined according to these results.
Important aspects to consider about the ERA Test:
It is vitally important that the test and treatment are planned by holding the frozen embryo transfer as the basis for the couples to gain maximum benefit from the test.
In other words, the ERA test is not a suitable test for treatments that use fresh egg transfers that have been stimulated with hormones.
The clinic conducting the ERA test must also be specialised in frozen embryo transfers and procedures to achieve a high rate of success.